Pharmacokinetic Interaction of Chrysin with Caffeine in Rats


Pharmacokinetic interaction of chrysin, a flavone present in honey, propolis and herbs, with caffeine was investigated in male Sprague-Dawley rats. Because chrysin inhibited CYP1A-selective ethoxyresorufin O-deethylase and methoxyresorufin O-demethylase activities in enriched rat liver microsomes, the pharmacokinetics of caffeine, a CYP 1A substrate, was… (More)
DOI: 10.4062/biomolther.2015.197


5 Figures and Tables

Slides referencing similar topics