Pharmacokinetic Interaction between Warfarin and Efonidipine in Rats

@article{Choi2011PharmacokineticIB,
  title={Pharmacokinetic Interaction between Warfarin and Efonidipine in Rats},
  author={Dong-Hyun Choi and Jun-shik Choi},
  journal={Journal of Pharmaceutical Investigation},
  year={2011},
  volume={41},
  pages={273-278}
}
  • D. Choi, Jun-shik Choi
  • Published 20 October 2011
  • Chemistry, Biology, Medicine
  • Journal of Pharmaceutical Investigation
ABSTRACT − The aim of this study was to investigate the effect of efonidipine on the pharmacokinetics of warfarin afteroral and intravenous administration of warfarin in rats. Warfarin was administered orally (0.2 mg/kg) or intravenously (0.05mg/kg) without or with oral administration of efonidipine (1 or 3 mg/kg) in rats. The effect of efonidipine on the cytochromeP450 (CYP) 3A4 activity was also evaluated. Efonidipine inhibited CYP3A4 enzyme activity with 50% inhibition con-centration (IC 50… 

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