Pharmacokinetic Drug Interactions with Oral Contraceptives

@article{Back1990PharmacokineticDI,
  title={Pharmacokinetic Drug Interactions with Oral Contraceptives},
  author={David Back and M. L. E. Orme},
  journal={Clinical Pharmacokinetics},
  year={1990},
  volume={18},
  pages={472-484}
}
  • D. BackM. Orme
  • Published 1 June 1990
  • Medicine, Biology
  • Clinical Pharmacokinetics
SummaryOral contraceptive steroids are used by an estimated 60 to 70 million women worldwide. Over the past 20 years there have been both case reports and clinical studies on the topic of drug interactions with these agents. Some of the interactions are of definite therapeutic relevance, whereas others can be discounted as being of no clinical significance. Pharmacological interactions between oral contraceptive steroids and other compounds may be of 2 kinds: (a) drugs may impair the efficacy… 

Antibiotic and oral contraceptive drug interactions: Is there a need for concern?

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Drug‐Drug Interaction Studies With Oral Contraceptives: Pharmacokinetic/Pharmacodynamic and Study Design Considerations

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Interactions Between Antiepileptic Drugs and Hormonal Contraception

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Pharmacokinetic Drug Interactions Between Oral Contraceptives and Second-Generation Anticonvulsants

On the basis of available study data in women receiving concomitant OC preparations, gabapentin, lamotrigine, tiagabine and vigabatrin may be administered without significant pharmacokinetic interactions that potentially diminish contraceptive efficacy.

Antibiotics and oral contraceptives.

No Interaction between Ciprofloxacin and an Oral Contraceptive

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It is suggested that the effects of such interaction might be presented in terms of increased incidence of side effects, including water retention, diabetogenic effects, hypertension, and an increased risk of thromboembolic disorders.

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  • Medicine, Biology
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It now is accepted that rifampicin and anticonvulsants such as phenobarbitone phenytoin and carbamazepine may cause contraceptive failure in women taking OCs and broad spectrum antibiotics do cause a significant fall in plasma concentrations of steroids.

Drug interactions with oral contraceptive preparations

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  • Medicine, Biology
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It is safer for the present to assuume that all women who take OCs might be at risk of some form of interaction, and these interactions might be expected to become less common as the concentration of estrogen in OCS decreases.

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By stimulating the formation of enzymes that increase the rate of metabolism of the oral contraceptive, the concentration of steroids in the plasma falls to levels inadequate for the control of conception.

Drug interactions with oral contraceptive steroids.

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