Pharmacokinetic Drug Interactions with Oral Contraceptives

  title={Pharmacokinetic Drug Interactions with Oral Contraceptives},
  author={David Back and M. L. E. Orme},
  journal={Clinical Pharmacokinetics},
  • D. BackM. Orme
  • Published 1 June 1990
  • Medicine, Biology
  • Clinical Pharmacokinetics
SummaryOral contraceptive steroids are used by an estimated 60 to 70 million women worldwide. Over the past 20 years there have been both case reports and clinical studies on the topic of drug interactions with these agents. Some of the interactions are of definite therapeutic relevance, whereas others can be discounted as being of no clinical significance. Pharmacological interactions between oral contraceptive steroids and other compounds may be of 2 kinds: (a) drugs may impair the efficacy… 

Antibiotic and oral contraceptive drug interactions: Is there a need for concern?

Rifampin is the only antibiotic to date that has been reported to reduce plasma estrogen concentrations and oral contraceptives cannot be relied upon for birth control while taking rifampsin, and other antibiotics are most likely safe to use concomitantly with oral contraceptives.

Drug‐Drug Interaction Studies With Oral Contraceptives: Pharmacokinetic/Pharmacodynamic and Study Design Considerations

This review provides a comprehensive overview of various factors that need to be considered in designing OC DDI studies and recommends PK‐based D DI studies with PK end points as adequate measures to establish clinical drug interaction and measurement of PD end points when there is basis for PD interaction.

Interactions Between Antiepileptic Drugs and Hormonal Contraception

There are no interactions between the combined oral contraceptive pill, progesterone-only pill, medroxyprogesterone injections or levonorgestrel implants or AEDs valproic acid (sodium valproate), vigabatrin, lamotrigine, gabapentin, tiagabine, levetiracetam, zonisamide, ethosuximide and the benzodiazepines.

Pharmacokinetic Drug Interactions Between Oral Contraceptives and Second-Generation Anticonvulsants

On the basis of available study data in women receiving concomitant OC preparations, gabapentin, lamotrigine, tiagabine and vigabatrin may be administered without significant pharmacokinetic interactions that potentially diminish contraceptive efficacy.

Antibiotics and oral contraceptives.

No Interaction between Ciprofloxacin and an Oral Contraceptive

It is concluded that ciprofloxacin does not interfere with the ovarian suppression produced by the low-dose oral contraceptive Marvelon, and no clinically significant differences in the levels of sex hormone binding globulin were found.



Drug Interactions with Oral Contraceptives

  • P. D’arcy
  • Medicine, Biology
    Family planning information service
  • 1978
It is suggested that the effects of such interaction might be presented in terms of increased incidence of side effects, including water retention, diabetogenic effects, hypertension, and an increased risk of thromboembolic disorders.

Interactions between oral contraceptive steroids and broad‐spectrum antibiotics

  • M. OrmeD. Back
  • Medicine, Biology
    Clinical and experimental dermatology
  • 1986
It now is accepted that rifampicin and anticonvulsants such as phenobarbitone phenytoin and carbamazepine may cause contraceptive failure in women taking OCs and broad spectrum antibiotics do cause a significant fall in plasma concentrations of steroids.

Drug interactions with oral contraceptive preparations

  • G. Shenfield
  • Medicine, Biology
    The Medical journal of Australia
  • 1986
It is safer for the present to assuume that all women who take OCs might be at risk of some form of interaction, and these interactions might be expected to become less common as the concentration of estrogen in OCS decreases.

The clinical pharmacology of oral contraceptive steroids.

The total dose level cannot be reduced much further without impairing the contraceptive efficacy of the drug, and it is likely that the majority of women are not at risk of contraceptive failure when using a broad spectrum antibiotic at the same time as the OC.

Interactions between oral Yvonne contraceptives and other drugs: a review

By stimulating the formation of enzymes that increase the rate of metabolism of the oral contraceptive, the concentration of steroids in the plasma falls to levels inadequate for the control of conception.

Drug interactions with oral contraceptive steroids.

Because of the wide variation in response, women using rifampicin should not use OCs, especially low-dose OCs and ascorbic acid has recently been found to enhance the effect of OCs.

Interactions between oral contraceptives and other drugs.

Antacid does not reduce the bioavailability of oral contraceptive steroids in women.

No effect of antacid administration on bioavailability of any contraceptive steroid was observed as judged by peak levels and areas under concentration-time curve (AUC), but significantly higher serum concentrations of EE2 were observed when it was administered in combination with NET than with LNg.

Alterations in prednisolone disposition as a result of oral contraceptive use and dose.

The disposition of total and free prednisolone has been studied in eight female subjects who used combined oestrogen-progestogen oral contraceptives and in eight female subjects who did not, each of