Pharmacokinetic Drug Interactions of Gefitinib with Rifampicin, Itraconazole and Metoprolol

@article{Swaisland2005PharmacokineticDI,
  title={Pharmacokinetic Drug Interactions of Gefitinib with Rifampicin, Itraconazole and Metoprolol},
  author={Helen C. Swaisland and Malcolm R Ranson and Robert P. Smith and Joanna Leadbetter and Alison Laight and D. Mckillop and Martin Wild},
  journal={Clinical Pharmacokinetics},
  year={2005},
  volume={44},
  pages={1067-1081}
}
AbstractBackground and objectives: Gefitinib (IRESSA®, ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, has been approved in several countries for the treatment of advanced non-small-cell lung cancer. Preclinical studies were conducted to determine the cytochrome P450 (CYP) isoenzymes involved in the metabolism of gefitinib and to evaluate the potential of gefitinib to cause drug interactions through inhibition of CYP isoenzymes. Based on these findings, three clinical… 

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