Pharmacokinetic Determinants of Drug Abuse and Dependence

@article{Busto1986PharmacokineticDO,
  title={Pharmacokinetic Determinants of Drug Abuse and Dependence},
  author={Usoa E. Busto and Edward Sellers},
  journal={Clinical Pharmacokinetics},
  year={1986},
  volume={11},
  pages={144-153}
}
SummaryDrugs that produce physical dependence or have similar pharmacological profiles to highly abused drugs are unlikely to be considered acceptable for marketing. Thus, the prediction of abuse and dependence becomes an important issue in the development of new psychotropic drugs.Both pharmacokinetic and non-pharmacokinetic factors play an important role in predicting dependence and abuse liability of drugs. Evidence for the importance of pharmacological factors includes: (a) the… 
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