Pharmacokinetic Consequences of PLGA Nanoparticles in Docetaxel Drug Delivery.

  title={Pharmacokinetic Consequences of PLGA Nanoparticles in Docetaxel Drug Delivery.},
  author={Pedram Rafiei and Azita Haddadi},
  journal={Pharmaceutical nanotechnology},
  volume={5 1},
BACKGROUND Cancer chemotherapy is accompanied with administration of highly potent cytotoxic agents in doses that can result in non-specific drug toxicity and side effects. Chemotherapeutic agents possess limitations such as lack of water solubility, high volume of distribution, poor bioavailability, narrow therapeutic indices, multi-drug resistance, etc. that raise serious matters of concern regarding drug's pharmaceutical and clinical aspects. However, application of nanoparticles in delivery… CONTINUE READING

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