Pharmacokinetic Consequences of Active Drug Efflux at the Blood–Brain Barrier

The objective of this simulation study was to investigate how the nature, location, and capacity of the efflux processes in relation to the permeability properties influence brain concentrations. Reduced brain concentrations can be due to either influx hindrance, a gatekeeper function in the luminal membrane, which has been suggested for ABCB1 (P… CONTINUE READING