Pharmacokinetic/pharmacodynamic relationships of asparaginase formulations: the past, the present and recommendations for the future.

@article{Avramis2005PharmacokineticpharmacodynamicRO,
  title={Pharmacokinetic/pharmacodynamic relationships of asparaginase formulations: the past, the present and recommendations for the future.},
  author={Vassilios I. Avramis and Eduard H. Panosyan},
  journal={Clinical pharmacokinetics},
  year={2005},
  volume={44 4},
  pages={367-93}
}
The discovery of the tumour-inhibitory properties of asparaginase began 50 years ago with the observation that guinea-pig serum-treated lymphoma-bearing mice underwent rapid and often complete regression. Soon afterwards, the asparaginase of bacterial origin was isolated. The asparaginases of bacterial origin induce anti-asparaginase neutralising antibodies in a large proportion of patients (44-60%), thus negating the specific enzymatic activity and resulting in failure of the target amino acid… CONTINUE READING

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