Pharmacokinetic/Pharmacodynamic Modeling of Renin-Angiotensin Aldosterone Biomarkers Following Angiotensin-Converting Enzyme (ACE) Inhibition Therapy with Benazepril in Dogs

@article{Mochel2014PharmacokineticPharmacodynamicMO,
  title={Pharmacokinetic/Pharmacodynamic Modeling of Renin-Angiotensin Aldosterone Biomarkers Following Angiotensin-Converting Enzyme (ACE) Inhibition Therapy with Benazepril in Dogs},
  author={Jonathan P Mochel and Martin Fink and Mathieu Peyrou and Antoine Soubret and J{\'e}r{\^o}me M. Giraudel and Meindert Danhof},
  journal={Pharmaceutical Research},
  year={2014},
  volume={32},
  pages={1931-1946}
}
PurposeThe objective of this research was to provide a comprehensive description of the effect of benazepril on the dynamics of the renin-angiotensin aldosterone system (RAAS) in dogs.MethodsBlood specimens for renin activity (RA), angiotensin II (AII), and aldosterone (ALD) quantitation in plasma were drawn from 12 healthy adult beagle dogs randomly allocated to 2 treatment groups: (i) benazepril 5 mg PO, q24 h (n: 6) and (ii) placebo (n: 6), in a cross-over design. A mechanism-based… CONTINUE READING

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