Pharmacokinetic/Pharmacodynamic Evaluation of Deflazacort in Comparison to Methylprednisolone and Prednisolone

@article{Mllmann1995PharmacokineticPharmacodynamicEO,
  title={Pharmacokinetic/Pharmacodynamic Evaluation of Deflazacort in Comparison to Methylprednisolone and Prednisolone},
  author={Helmut M{\"o}llmann and G{\"u}nther Hochhaus and Shashank Rohatagi and J{\"u}rgen Barth and Hartmut Derendorf},
  journal={Pharmaceutical Research},
  year={1995},
  volume={12},
  pages={1096-1100}
}
AbstractPurpose. The pharmacokinetics and pharmacodynamics of deflazacort after oral administration (30 mg) to healthy volunteers were determined and compared with those of 20 mg of methylprednisolone and 25 mg of prednisolone. Methods. Methylprednisolone, prednisolone and the active metabolite of deflazacort, 21-desacetyldeflazacort, were measured in plasma using HPLC. For the assessment of pharmacodynamics, differential white blood cell counts were obtained over 24 hours. An integrated… 

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