Pharmacogenomics of organic anion-transporting polypeptides (OATP).

  title={Pharmacogenomics of organic anion-transporting polypeptides (OATP).},
  author={Rommel G. Tirona and Richard B Kim},
  journal={Advanced drug delivery reviews},
  volume={54 10},
The organic anion-transporting polypeptides (OATP) represent a family of proteins responsible for the membrane transport of a large number of endogenous and xenobiotic compounds with diverse chemical characteristics. OATPs are expressed in liver, kidney, brain and intestine suggesting that they may play a critical role in drug disposition. Naturally occurring polymorphisms in OATPs are currently being identified and for some, in vitro transport activities have been characterized. In this… CONTINUE READING