Pharmacogenomics of adverse drug reactions: implementing personalized medicine.

  title={Pharmacogenomics of adverse drug reactions: implementing personalized medicine.},
  author={Chun-yu Wei and Ming Ta Michael Lee and Yuan-Tsong Chen},
  journal={Human molecular genetics},
  volume={21 R1},
Pharmacogenomics aims to investigate the genetic basis of inter-individual differences in drug responses, such as efficacy, dose requirements and adverse events. Research in pharmacogenomics has grown over the past decade, evolving from a candidate-gene approach to genome-wide association studies (GWASs). Genetic variants in genes coding for drug metabolism, drug transport and more recently human-leukocyte antigens (HLAs) have been linked to inter-individual differences in the risk of adverse… CONTINUE READING
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