Pharmacogenomics of Scopoletin in Tumor Cells.

  title={Pharmacogenomics of Scopoletin in Tumor Cells.},
  author={Ean-Jeong Seo and Mohamed E. M. Saeed and Betty Yuen-kwan Law and An-Guo Wu and Onat Kadioglu and Henry Johannes Greten and Thomas H Efferth},
  volume={21 4},
Drug resistance and the severe side effects of chemotherapy necessitate the development of novel anticancer drugs. Natural products are a valuable source for drug development. Scopoletin is a coumarin compound, which can be found in several Artemisia species and other plant genera. Microarray-based RNA expression profiling of the NCI cell line panel showed that cellular response of scopoletin did not correlate to the expression of ATP-binding cassette (ABC) transporters as classical drug… CONTINUE READING
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