Pharmacogenomics of CYP2A6, CYP2B6, CYP2C19, CYP2D6, CYP3A4, CYP3A5 and MDR1 in Vietnam

  title={Pharmacogenomics of CYP2A6, CYP2B6, CYP2C19, CYP2D6, CYP3A4, CYP3A5 and MDR1 in Vietnam},
  author={M. I. Veiga and S. Asimus and P. E. Ferreira and J. Martins and I. Cavaco and V. Ribeiro and T. Hai and M. Petzold and A. Bj{\"o}rkman and M. Ashton and J. P. Gil},
  journal={European Journal of Clinical Pharmacology},
  • M. I. Veiga, S. Asimus, +8 authors J. P. Gil
  • Published 2008
  • Biology, Medicine
  • European Journal of Clinical Pharmacology
  • AimThe aim of this study was to obtain pharmacogenetic data in a Vietnamese population on genes coding for proteins involved in the elimination of drugs currently used for the treatment of malaria and human immunodeficiency virus/acquired immunodeficiency syndrome.MethodThe main polymorphisms on the cytochrome P450 (CYP) genes, CYP2A6, CYP2B6, CYP2C19, CYP2D6, CYP3A4 and CYP3A5, and the multi-drug resistance 1 gene (MDR1) were genotyped in 78 healthy Vietnamese subjects. Pharmacokinetic metrics… CONTINUE READING
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