Pharmacogenomics in the intensive care unit: focus on potential implications for clinical practice.

@article{Allen2014PharmacogenomicsIT,
  title={Pharmacogenomics in the intensive care unit: focus on potential implications for clinical practice.},
  author={J. M. Allen and S. Gelot},
  journal={Recent patents on biotechnology},
  year={2014},
  volume={8 2},
  pages={
          116-22
        }
}
Critically ill patients often are at high-risk for adverse drug reactions (ADRs), mainly due to alterations in pharmacokinetic and pharmacodynamic (PK/PD) parameters. These PK/PD differences in can also lead to inadequate therapeutic response to many commonly used drugs in this patient population. Frequently in the critically ill patient, medications are utilized based on a "trial-and-error" approach. Furthermore, drug dosing in the critically ill largely remains a "one-size-fits-all… Expand
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