Pharmacogenomics and individualized drug therapy.

@article{Eichelbaum2006PharmacogenomicsAI,
  title={Pharmacogenomics and individualized drug therapy.},
  author={M. Eichelbaum and M. Ingelman-Sundberg and W. Evans},
  journal={Annual review of medicine},
  year={2006},
  volume={57},
  pages={
          119-37
        }
}
Pharmacogenetics deals with inherited differences in the response to drugs. The best-recognized examples are genetic polymorphisms of drug-metabolizing enzymes, which affect about 30% of all drugs. Loss of function of thiopurine S-methyltransferase (TPMT) results in severe and life-threatening hematopoietic toxicity if patients receive standard doses of mercaptopurine and azathioprine. Gene duplication of cytochrome P4502D6 (CYP2D6), which metabolizes many antidepressants, has been identified… Expand
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