Pharmacogenomics and colorectal cancer.

  title={Pharmacogenomics and colorectal cancer.},
  author={Heinz-Josef Lenz},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  volume={15 Suppl 4},
The current methods of treating cancer patients with chemotherapeutics do not account for interpatient variability in the expression of particular target genes. This variability leads to unpredictable tumor responses and host toxicity. The approach we have taken is to determine gene expression levels in the metabolic pathways of drugs used in the treatment… CONTINUE READING