Pharmacogenomic effect of vitamin E on kidney structure and function in transgenic mice with the haptoglobin 2-2 genotype and diabetes mellitus.

@article{Nakhoul2009PharmacogenomicEO,
  title={Pharmacogenomic effect of vitamin E on kidney structure and function in transgenic mice with the haptoglobin 2-2 genotype and diabetes mellitus.},
  author={Farid Nakhoul and Rachel Miller-Lotan and Hassoup Awad and Rabea Asleh and Kheir Jad and Nakhoul Nakhoul and Roy Asaf and Niroz Abu-saleh and Andrew P. Levy},
  journal={American journal of physiology. Renal physiology},
  year={2009},
  volume={296 4},
  pages={
          F830-8
        }
}
Polymorphic loci regulating oxidative stress are potential susceptibility genes for diabetic nephropathy (DN). Haptoglobin (Hp) is an antioxidant protein which serves to protect against oxidative stress induced by extracorpuscular hemoglobin. There are two alleles at the Hp locus, 1 and 2. The Hp 1 protein is a superior antioxidant to the Hp 2 protein. The Hp 2 allele has been associated with increased prevalence of DN and appears to be associated with a more rapid progression to end-stage… 
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