Pharmacogenomic effect of vitamin E on kidney structure and function in transgenic mice with the haptoglobin 2-2 genotype and diabetes mellitus.

@article{Nakhoul2009PharmacogenomicEO,
  title={Pharmacogenomic effect of vitamin E on kidney structure and function in transgenic mice with the haptoglobin 2-2 genotype and diabetes mellitus.},
  author={Farid Nakhoul and Rachel Miller-Lotan and Hassoup Awad and Rabea Asleh and Kheir Jad and Nakhoul Nakhoul and Roy Asaf and Niroz Abu-saleh and Andrew P. Levy},
  journal={American journal of physiology. Renal physiology},
  year={2009},
  volume={296 4},
  pages={
          F830-8
        }
}
Polymorphic loci regulating oxidative stress are potential susceptibility genes for diabetic nephropathy (DN). Haptoglobin (Hp) is an antioxidant protein which serves to protect against oxidative stress induced by extracorpuscular hemoglobin. There are two alleles at the Hp locus, 1 and 2. The Hp 1 protein is a superior antioxidant to the Hp 2 protein. The Hp 2 allele has been associated with increased prevalence of DN and appears to be associated with a more rapid progression to end-stage… 
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Haptoglobin Polymorphism as a Risk Factor for Chronic Kidney Disease: A Case-Control Study
TLDR
It is shown that Hp2-2 genotype is an independent risk factor for CKD, together with diabetes, hypertension, hypertension and dyslipidemia.
Haptoglobin genotype and its role in determining heme-iron mediated vascular disease.
Haptoglobin 2-2 genotype is associated with increased risk of type 2 diabetes mellitus in northern Chinese.
TLDR
The results showed that the Hp2-2 genotype is associated with increased risk of T2DM in the northern Chinese Han population.
The Non Mineral Axis Klotho-Vitamin D in Diabetic Nephropathy: Review
TLDR
The aim of this review is to understand the importance of klotho protein and vitamin D in the pathogenesis of DN and as a potential future target for treatment.
Poor lysosomal membrane integrity in proximal tubule cells of haptoglobin 2-2 genotype mice with diabetes mellitus.
Haptoglobin Genotype and Renal Function Decline in Type 1 Diabetes
TLDR
Although Hp genotype is not associated with albuminuria per se, it may be an independent determinant of early renal function decline and progression to ESRD, suggesting further insight into the pathogenesis of renal disease in type 1 diabetes.
Haptoglobin genotype modifies the association between dietary vitamin C and serum ascorbic acid deficiency.
TLDR
The findings suggest that the greater antioxidant capacity of Hp1 might spare serum ascorbic acid.
New Insights into the Interaction between Increased Iron-Deposition in the Kidney and Vitamin D/Klotho Axis in Diabetic Nephropathy
TLDR
New pathways involved in the pathogenesis of diabetic nephropathy are described to describe, including the increased production of free radicals via oxidative stress due to increased iron deposition in the lysosomes of the proximal convolute tubules.
Antioxidant, Anti-Inflammatory, and Metabolic Properties of Tocopherols and Tocotrienols: Clinical Implications for Vitamin E Supplementation in Diabetic Kidney Disease
TLDR
A review of the literature about the role of vitamin E supplementation on diabetic nephropathy is performed, also describing the underlying antioxidant, anti-inflammatory, and metabolic mechanisms to evaluate the possible use of tocopherols and tocotrienols in clinical practice.
Meta-analysis of the association of the haptoglobin genotype with cardiovascular outcomes and the pharmacogenomic interactions with vitamin E supplementation
TLDR
The Hp genotype is a risk factor for CV events in patients with DM, and administration of vitamin E appears to offer a low cost and accessible means of reducing CV events and mortality in this population.
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