Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity.

Abstract

Disease relapse sometimes occurs after acute promyelocytic leukemia (APL) therapy with all-trans retinoic acid (ATRA). Among the diagnostic parameters predicting relapse, heterogeneity in the in vitro differentiation rate of blasts is an independent factor. To identify biologic networks involved in resistance, we conducted pharmacogenomic studies in APL… (More)

Topics

Cite this paper

@article{Quere2007PharmacogenomicAO, title={Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity.}, author={R. Quere and Aur{\'e}lie Baudet and Bruno Cassinat and G{\'e}rald Bertrand and Jacques Marti and Laurent Manchon and David Piquemal and Christine Chomienne and Therese Commes}, journal={Blood}, year={2007}, volume={109 10}, pages={4450-60} }