Pharmacogenetics of the human drug-transporter gene MDR1: impact of polymorphisms on pharmacotherapy.

@article{Brinkmann2001PharmacogeneticsOT,
  title={Pharmacogenetics of the human drug-transporter gene MDR1: impact of polymorphisms on pharmacotherapy.},
  author={Ulrich Brinkmann and Ivar Roots and Michel F Eichelbaum},
  journal={Drug discovery today},
  year={2001},
  volume={6 16},
  pages={835-839}
}
The blood- and tissue-concentrations, and thus the activity, of many drugs are influenced by factors that are subject to inter-individual variation. Variables that influence blood levels are metabolizing enzymes and transporters. Transporters control drug uptake, distribution and elimination. Transport by efflux pumps such as MDR1-encoded P-glycoprotein can influence the bioavailability of drugs. Knowledge of the transporter 'status' might allow for compensation of differences in drug uptake… CONTINUE READING