Pharmacogenetics of the G protein-coupled receptors.

  title={Pharmacogenetics of the G protein-coupled receptors.},
  author={Miles D. Thompson and David E. C. Cole and Val{\'e}rie Capra and Katherine Anne Siminovitch and Gianenrico Rovati and W. McIntyre Burnham and Brinda K. Rana},
  journal={Methods in molecular biology},
Pharmacogenetics investigates the influence of genetic variants on physiological phenotypes related to drug response and disease, while pharmacogenomics takes a genome-wide approach to advancing this knowledge. Both play an important role in identifying responders and nonresponders to medication, avoiding adverse drug reactions, and optimizing drug dose for the individual. G protein-coupled receptors (GPCRs) are the primary target of therapeutic drugs and have been the focus of these studies… CONTINUE READING
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