Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother

  title={Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother},
  author={G. Koren and James H. Cairns and D. Chitayat and A. Gaedigk and S. Leeder},
  journal={The Lancet},
  • G. Koren, James H. Cairns, +2 authors S. Leeder
  • Published 2006
  • Medicine
  • The Lancet
  • In April, 2005, a full-term healthy male infant, delivered vaginally, showed intermittent periods of diffi culty in breastfeeding and lethargy starting on day 7. During a well-baby paediatric visit on day 11, the paediatrician noted that the baby had regained his birthweight. On day 12, however, he had grey skin and his milk intake had fallen. He was found dead on day 13. Postmortem analysis showed no anatomical anomalies. Blood concentration of morphine (the active metabolite of codeine) was… CONTINUE READING
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