Pharmacogenetics of methotrexate.

@article{Krajinovic2004PharmacogeneticsOM,
  title={Pharmacogenetics of methotrexate.},
  author={Maja Krajinovic and Albert Moghrabi},
  journal={Pharmacogenomics},
  year={2004},
  volume={5 7},
  pages={
          819-34
        }
}
Methotrexate (MTX) has proven efficient in the treatment of a number of malignancies, as well as non-malignant disorders characterized by a rapid cellular growth. Yet some patients might develop resistance, while others could have toxic side effects. MTX achieves its cytotoxicity through the inhibition of folate-dependent enzymes, suggesting that the genes controlling their activity or the levels of folate cofactors can modulate drug efficacy and, thus, the sensitivity of a patient to MTX… CONTINUE READING
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