Pharmacogenetics of fluoropyrimidine and cisplatin. A future application to gastric cancer treatment.

@article{Shimoyama2009PharmacogeneticsOF,
  title={Pharmacogenetics of fluoropyrimidine and cisplatin. A future application to gastric cancer treatment.},
  author={Shouji Shimoyama},
  journal={Journal of gastroenterology and hepatology},
  year={2009},
  volume={24 6},
  pages={970-81}
}
Chemotherapy plays an important role in the treatment of gastric cancer both in adjuvant or advanced settings. Recent randomized trials in Japan have proved that S-1, a novel fluoropyrimidine derivative, and cisplatin are the most promising agents. However, both the efficacy and toxicity of a given regimen vary widely among patients due to the inherited variability of genes that involve drug anabolism and catabolism. A narrow therapeutic index of antitumor agents, i.e. a given regimen being too… CONTINUE READING