Pharmacogenetics of drug transporters in the enterohepatic circulation.

  title={Pharmacogenetics of drug transporters in the enterohepatic circulation.},
  author={Bruno Stieger and Peter Meier},
  volume={12 5},
This article summarizes the impact of the pharmacogenetics of drug transporters expressed in the enterohepatic circulation on the pharmacokinetics and pharmacodynamics of drugs. The role of pharmacogenetics in the function of drug transporter proteins in vitro is now well established and evidence is rapidly accumulating from in vivo pharmacokinetic studies, which suggests that genetic variants of drug transporter proteins can translate into clinically relevant phenotypes. However, a large… CONTINUE READING


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