Pharmacogenetics of drug-induced liver injury.

@article{Russmann2010PharmacogeneticsOD,
  title={Pharmacogenetics of drug-induced liver injury.},
  author={Stefan Russmann and Alexander Jetter and Gerd A Kullak-Ublick},
  journal={Hepatology},
  year={2010},
  volume={52 2},
  pages={748-61}
}
Recent progress in research on drug-induced liver injury (DILI) has been determined by key developments in two areas. First, new technologies allow the identification of genetic risk factors with improved sensitivity, specificity, and efficiency. Second, new mechanistic concepts of DILI emphasize the importance of unspecific "downstream" events following drug-specific initial "upstream" hepatocyte injury and of complex interactions between environmental and genetic risk factors. The integration… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 68 extracted citations

Drug-Induced Autoimmune-Like Hepatitis

Digestive Diseases and Sciences • 2011
View 10 Excerpts
Highly Influenced

Assessment of nonsteroidal anti-inflammatory drug-induced hepatotoxicity.

Expert opinion on drug metabolism & toxicology • 2011
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 111 references

Idiosyncratic drug hepatotoxicity

Nature Reviews Drug Discovery • 2005
View 4 Excerpts
Highly Influenced

Distribution and concordance of N-acetyltransferase genotype and phenotype in an American population.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 1999
View 2 Excerpts
Highly Influenced

Causation and Causal Inference

International Encyclopedia of Statistical Science • 2011

Similar Papers

Loading similar papers…