Pharmacogenetics of drug-induced liver injury.

  title={Pharmacogenetics of drug-induced liver injury.},
  author={Stefan Russmann and Alexander Jetter and Gerd A Kullak-Ublick},
  volume={52 2},
Recent progress in research on drug-induced liver injury (DILI) has been determined by key developments in two areas. First, new technologies allow the identification of genetic risk factors with improved sensitivity, specificity, and efficiency. Second, new mechanistic concepts of DILI emphasize the importance of unspecific "downstream" events following drug-specific initial "upstream" hepatocyte injury and of complex interactions between environmental and genetic risk factors. The integration… CONTINUE READING
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