Pharmacogenetics of drug dependence: role of gene variations in susceptibility and treatment.

@article{Khokhar2010PharmacogeneticsOD,
  title={Pharmacogenetics of drug dependence: role of gene variations in susceptibility and treatment.},
  author={Jibran Y. Khokhar and Charmaine S Ferguson and Andy Z. X. Zhu and Rachel F. Tyndale},
  journal={Annual review of pharmacology and toxicology},
  year={2010},
  volume={50},
  pages={
          39-61
        }
}
Drug dependency is a highly prevalent mental health disorder that imposes a significant burden on those directly affected, health care systems, and society in general. There is substantial heritability in the susceptibility to drug addiction, which indicates that there are genetic risk factors. Variation in the human genome is abundant and can directly affect drug dependency phenotypes, for example, by altering the function of a gene product or by altering gene expression. Pharmacogenetic… CONTINUE READING

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