Pharmacogenetics of deoxycytidine kinase: identification and characterization of novel genetic variants.

  title={Pharmacogenetics of deoxycytidine kinase: identification and characterization of novel genetic variants.},
  author={Jatinder Lamba and Kristine Crews and Stanley B Pounds and Erin G. Schuetz and Jessica Gresham and Varsha Gandhi and William Plunkett and Jeffrey Rubnitz and Raul C. Ribeiro},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={323 3},
Deoxycytidine kinase (DCK) is a rate-limiting enzyme in the activation of nucleoside analogs such as cytarabine (ara-C), gemcitabine, clofarabine, and others. The present study was undertaken to identify and to determine the functional consequences of genetic variants in DCK. We sequenced 1.5 kilobases of the DCK proximal promoter and all seven coding exons in International HapMap Project panels (n = 90 each) with European (Centre d' Etude du Polymorphisme Humain; CEPH) or African (Yoruba… CONTINUE READING


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