Pharmacogenetics of antipsychotics: useful for the clinician?

@article{Bondy2007PharmacogeneticsOA,
  title={Pharmacogenetics of antipsychotics: useful for the clinician?},
  author={Brigitta Bondy and Ilja Spellmann},
  journal={Current Opinion in Psychiatry},
  year={2007},
  volume={20},
  pages={126–130}
}
Purpose of review The concept of individualized drug therapy on the basis of pharmacogenetics has become a central focus in psychopharmacology of schizophrenia. This article reviews recent advances in this field with respect to their importance for the clinician. Recent findings First, there is an increasing agreement about the importance of polymorphisms in cytochrome P450 enzymes and the effects of drug–drug interactions in relation to the incidence of adverse effects. Secondly, prediction of… Expand
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References

SHOWING 1-10 OF 57 REFERENCES
The role of 5-HT2C receptor polymorphisms in the pharmacogenetics of antipsychotic drug treatment
The development of novel, atypical antipsychotics has been welcomed due to their lower incidence of extrapyramidal side effects. However, as with all pharmacotherapy, patient response is often variedExpand
The emerging role of pharmacogenetics: implications for clinical psychiatry.
TLDR
Genotyping, especially for drug metabolizing enzymes, could enable more rational, cost-effective and optimal prescribing in future psychopharmacotherapy and must also be considered as cultural and environmental factors significantly impinge on response to medications. Expand
Pharmacogenomics in schizophrenia: the quest for individualized therapy.
TLDR
This review will provide demonstrative examples of functional candidate gene variants studied in a variety of antipsychotic response phenotypes in the treatment of schizophrenia, and the merits and weaknesses of neuroimaging technologies as applied to pharmacogenetic analyses are discussed. Expand
Pharmacogenetics of antipsychoatics.
  • N. Ozaki
  • Medicine
  • Nagoya journal of medical science
  • 2004
TLDR
The new field of pharmacogenomics using DNA microarray analysis, which focuses on the genetic determinants of drug response at the level of the entire human genome, is important for development and prescription of safer and more effective individually-tailored antipsychotics. Expand
Pharmacogenomics: a path to predictive medicine for schizophrenia.
TLDR
This review summarizes the available knowledge of associations between pharmacogenetics and drug response in schizophrenia and presents a network model of the interaction/crosstalk between the neurotransmitter signaling systems to emphasize the importance of the genes associated with the molecular mechanisms of the disease and drugresponse. Expand
Pharmacogenetics of antipsychotic-induced weight gain
TLDR
Pharmacogenetic studies can provide powerful tools for the pre-treatment identification of individuals at high risk for antipsychotic-induced weight gain, to uncover biological mechanisms that may even generalize to non-drug-inducedWeight gain, and to isolate novel targets for treatments of weight gain and obesity. Expand
Pharmacogenetics of schizophrenia
TLDR
With improvements in defining the response phenotype in carefully assessed and homogeneous subject groups, the near future is likely to see the identification of genetic predictors of outcome that may inform the choice of pharmacotherapy. Expand
Pharmacogenetics of Drug Metabolising Enzymes: Importance for Personalised Medicine
  • M. Oscarson
  • Medicine
  • Clinical chemistry and laboratory medicine
  • 2003
TLDR
In order to apply the increasing amount of pharmacogenetic knowledge to clinical practise, specific dosage recommendations based on genotypes will have to be developed to guide the clinician, and these recommendations will haveTo be evaluated in prospective clinical studies. Expand
Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response
TLDR
Combinations of polymorphisms in pharmacokinetic and pharmacodynamic pathways of relevance might contribute to identify genotypes associated with best and worst responders and they may also identify susceptibility to adverse drug reactions. Expand
The Influence of Cytochrome P450 Pharmacogenetics on Disposition of Common Antidepressant and Antipsychotic Medications
TLDR
Although CYP genotyping has been shown to predict the majority of aberrant phenotypes, it is currently rarely performed in clinical practice and may be an important reason for drug therapy failure. Expand
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1
2
3
4
5
...