Pharmacogenetics of antimalarial drugs: effect on metabolism and transport.

  title={Pharmacogenetics of antimalarial drugs: effect on metabolism and transport.},
  author={Reinhold Kerb and Richard Fux and Klaus E M{\"o}rike and Peter Gottfried Kremsner and Jos{\'e} Pedro Gil and Christoph H. Gleiter and Matthias Schwab},
  journal={The Lancet. Infectious diseases},
  volume={9 12},
The prevention and management of malaria is primarily based on the use of drugs. Clinical trials have however revealed that between individuals there is large variability in the pharmacokinetic profiles of many antimalarial drugs. The resulting variations in concentrations of the drug within plasma might lead to either suboptimum effectiveness or drug… CONTINUE READING