Pharmacogenetics of Thiopurine S-Methyltransferase and Thiopurine Therapy

@article{Evans2004PharmacogeneticsOT,
  title={Pharmacogenetics of Thiopurine S-Methyltransferase and Thiopurine Therapy},
  author={William E. Evans},
  journal={Therapeutic Drug Monitoring},
  year={2004},
  volume={26},
  pages={186-191}
}
  • W. Evans
  • Published 1 April 2004
  • Biology, Medicine
  • Therapeutic Drug Monitoring
Abstract: Most medications exhibit wide interpatient variability in their efficacy and toxicity. For many medications, these interindividual differences result in part from polymorphisms in genes encoding drug-metabolizing enzymes, drug transporters, and/or drug targets (eg, receptors, enzymes). Pharmacogenomics is a burgeoning field aimed at elucidating the genetic basis of differences in drug efficacy and toxicity, using genome-wide approaches to identify the network of genes that govern an… 
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205 Citations
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205 Citations

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  • T. M. Bosch
  • Biology, Medicine
    Methods in molecular biology
  • 2008
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The murine model recapitulates many clinical features of the human polymorphism; indicates that mercaptopurine is more affected by the TPMT polymorphism than thioguanine; and provides a preclinical system for establishing safer regimens of genetically influenced antileukemic drug therapy.

Pharmacogenetics in inflammatory bowel disease.

The variants in genes that influence either the efficacy or toxicity of common drugs used in the treatment of inflammatory bowel diseases (IBD), ulcerative colitis (UC), and Crohn's disease (CD) are described.

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The variants in genes that influence either the efficacy or toxicity of common drugs used in the treatment of inflammatory bowel diseases (IBD), ulcerative colitis, and Crohn’s disease are described.

Azathioprine/6-mercaptopurine toxicity: The role of the TPMT gene

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...

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