Pharmacogenetics of Thiopurine S-Methyltransferase and Thiopurine Therapy

  title={Pharmacogenetics of Thiopurine S-Methyltransferase and Thiopurine Therapy},
  author={W. Evans},
  journal={Therapeutic Drug Monitoring},
  • W. Evans
  • Published 2004
  • Biology, Medicine
  • Therapeutic Drug Monitoring
  • Abstract: Most medications exhibit wide interpatient variability in their efficacy and toxicity. For many medications, these interindividual differences result in part from polymorphisms in genes encoding drug-metabolizing enzymes, drug transporters, and/or drug targets (eg, receptors, enzymes). Pharmacogenomics is a burgeoning field aimed at elucidating the genetic basis of differences in drug efficacy and toxicity, using genome-wide approaches to identify the network of genes that govern an… CONTINUE READING
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