Pharmacogenetics of Thiopurine S-Methyltransferase and Thiopurine Therapy

@article{Evans2004PharmacogeneticsOT,
  title={Pharmacogenetics of Thiopurine S-Methyltransferase and Thiopurine Therapy},
  author={W. Evans},
  journal={Therapeutic Drug Monitoring},
  year={2004},
  volume={26},
  pages={186-191}
}
  • W. Evans
  • Published 2004
  • Biology, Medicine
  • Therapeutic Drug Monitoring
    • Abstract: Most medications exhibit wide interpatient variability in their efficacy and toxicity. For many medications, these interindividual differences result in part from polymorphisms in genes encoding drug-metabolizing enzymes, drug transporters, and/or drug targets (eg, receptors, enzymes). Pharmacogenomics is a burgeoning field aimed at elucidating the genetic basis of differences in drug efficacy and toxicity, using genome-wide approaches to identify the network of genes that govern an… CONTINUE READING
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    References

    SHOWING 1-10 OF 58 REFERENCES
    Pharmacogenomics: the inherited basis for interindividual differences in drug response.
    • 389
    • PDF
    Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus.
    • 643
    • PDF
    High-throughput genotyping of thiopurine S-methyltransferase by denaturing HPLC.
    • 82
    • PDF
    Human thiopurine methyltransferase pharmacogenetics: Gene sequence polymorphisms
    • 390
    Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia
    • 400
    • PDF
    Thiopurine Methyltransferase Genotype Predicts Therapy-Limiting Severe Toxicity from Azathioprine
    • 362
    Thiopurine methyltransferase pharmacogenetics: human gene cloning and characterization of a common polymorphism.
    • 298
    Drug methylation in cancer therapy: lessons from the TPMT polymorphism
    • 123
    • PDF
    Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity.
    • 1,129
    Human liver thiopurine methyltransferase pharmacogenetics: biochemical properties, liver-erythrocyte correlation and presence of isozymes.
    • 215