Pharmacogenetics of Lipid-Lowering Agents: Precision or Indecision Medicine?

  title={Pharmacogenetics of Lipid-Lowering Agents: Precision or Indecision Medicine?},
  author={Jeffrey E Alfonsi and Robert A Hegele and Steven E Gryn},
  journal={Current atherosclerosis reports},
  volume={18 5},
Lipid-lowering medications, particularly statins, have been a popular target for pharmacogenetic studies. A handful of genes have shown promise for predicting response to therapy from the perspective of lipid lowering, as well as myopathy. A number of genes have been implicated and have biological plausibility based on their involvement with the pharmacokinetics or pharmacodynamics of statins or other lipid-lowering medications. The level of confidence and replication of these findings varies… CONTINUE READING