Pharmacogenetics of DNA repair gene polymorphisms in non-small-cell lung carcinoma patients on platinum-based chemotherapy.

@article{Zhang2014PharmacogeneticsOD,
  title={Pharmacogenetics of DNA repair gene polymorphisms in non-small-cell lung carcinoma patients on platinum-based chemotherapy.},
  author={Li Zhang and Weiyuan Ma and Yuan Li and J Wu and Guangyue Shi},
  journal={Genetics and molecular research : GMR},
  year={2014},
  volume={13 1},
  pages={228-36}
}
Individual differences in chemosensitivity and clinical outcome of non-small-cell lung carcinoma (NSCLC) patients can be influenced by host-inherited factors. We investigated the impact of XRCC1 Arg194Trp, XRCC1 Arg280His, XRCC1 Arg399Gln, XPD Arg156Arg, XPD Asp312Asn, XPD Asp711Asp, and XPD Lys751Gln gene polymorphisms on treatment efficacy in 375 NSCLC patients on platinum-based chemotherapy. We also examined progression-free survival and overall survival. The gene polymorphisms were analyzed… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Gene variants of XRCC 4 and XRCC 3 and their association with risk for urothelial bladder cancer

R Monaco, R Rosal, MA Dolan, MR Pincus
Mol . Biol . Rep • 2012

Genetic polymorphism of XRCC 1 Arg 399 Gln is associated with survival in non - small - cell lung cancer patients treated with gemcitabine / platinum

RM Lunn, RG Langlois, LL Hsieh, CL Thompson
J . Thorac . Oncol • 2012

adducts and glycophorin A variant frequency

Y Mi, L Zhang, N Feng, S Wu
Cancer Res • 2012
View 1 Excerpt

Similar Papers

Loading similar papers…