Pharmacogenetics of CYP2C19: functional and clinical implications of a new variant CYP2C19*17.

@article{LiWanPo2010PharmacogeneticsOC,
  title={Pharmacogenetics of CYP2C19: functional and clinical implications of a new variant CYP2C19*17.},
  author={Alain Li-Wan-Po and T. Girard and Peter A. Farndon and Candy Cooley and James K Lithgow},
  journal={British journal of clinical pharmacology},
  year={2010},
  volume={69 3},
  pages={
          222-30
        }
}
  • Alain Li-Wan-Po, T. Girard, +2 authors James K Lithgow
  • Published in
    British journal of clinical…
    2010
  • Medicine
  • AIMS Cytochrome P450 2C19 metabolizes many important drugs. In 2006, a variant allele (CYP2C19*17) associated with increased activity was discovered, but its likely clinical significance is controversial. Investigators disagree about the phenotype to be assigned to the two CYP2C19*17 genotypes. The aim of this study was to provide a critical summary, helpful to prescribers. METHODS We searched MEDLINE for papers on the allele from 2006 and then undertook historical searches through the… CONTINUE READING

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