Pharmacogenetics of CYP1A2, novel polymorphisms and haplotypes in three distinct Asian populations.

@article{Lim2010PharmacogeneticsOC,
  title={Pharmacogenetics of CYP1A2, novel polymorphisms and haplotypes in three distinct Asian populations.},
  author={Joanne Siok Liu Lim and Onkar Singh and Rathi Devi Ramasamy and Saminathan Ramasamy and Koilan Subramanian and Edmund Jon Deoon Lee and Balram Chowbay},
  journal={Drug metabolism and pharmacokinetics},
  year={2010},
  volume={25 6},
  pages={616-23}
}
CYP1A2 play an important role in the metabolism of many carcinogens and clinically important drugs. CYP1A2 activity has been found to be influenced by the presence of polymorphic variants which were reported to display wide interethnic variation. This study investigates the frequency distribution and linkage disequilibrium patterns of CYP1A2 genetic polymorphisms, and characterize their haplotype structures in three healthy Asian populations in Singapore (Chinese, Malay, and Indian). The entire… CONTINUE READING

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