Pharmacogenetics in drug discovery and development: a translational perspective

  title={Pharmacogenetics in drug discovery and development: a translational perspective},
  author={A. D. Roses},
  journal={Nature Reviews Drug Discovery},
The ability to predict a patient's drug response on the basis of their genetic information is expected to decrease attrition during the development of new, innovative drugs, and reduce adverse events by being able to predict individual patients at risk. Most pharmacogenetic investigations have focused on drug-metabolism genes or candidate genes that are thought to be involved in specific diseases. However, robust new genetic tools now enable researchers to carry out multi-candidate gene… CONTINUE READING