Pharmacogenetics for individualized cancer chemotherapy.

  title={Pharmacogenetics for individualized cancer chemotherapy.},
  author={Thomas H Efferth and M. Volm},
  journal={Pharmacology & therapeutics},
  volume={107 2},
The same doses of medication cause considerable heterogeneity in efficacy and toxicity across human populations. Genetic factors are thought to represent important determinants of drug efficacy and toxicity. Pharmacogenetics focuses on the prediction of the response of tumor and normal tissue to standard therapy by genetic profiling and, thereby, to select the most appropriate medication at optimal doses for each individual patient. In the present review, we discuss the relevance of single… CONTINUE READING