Pharmacogenetics and pharmacogenomics in rheumatology.

  title={Pharmacogenetics and pharmacogenomics in rheumatology.},
  author={Zolt{\'a}n Szekanecz and Bertalan Mesk{\'o} and Szil{\'a}rd P{\'o}liska and Andrea V{\'a}ncsa and Szilvia Szamosi and Edit V{\'e}gh and Enik{\"o} Simkovics and Judit Laki and J{\'u}lia Kurk{\'o} and Timea Besenyei and Katalin Mikecz and Tibor T. Glant and L{\'a}szl{\'o} Nagy},
  journal={Immunologic research},
  volume={56 2-3},
Pharmacogenetics and pharmacogenomics deal with possible associations of a single genetic polymorphism or those of multiple gene profiles with responses to drugs. In rheumatology, genes and gene signatures may be associated with altered efficacy and/or safety of anti-inflammatory drugs, disease-modifying antirheumatic drugs (DMARDs) and biologics. In brief, genes of cytochrome P450, other enzymes involved in drug metabolism, transporters and some cytokines have been associated with responses to… CONTINUE READING
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