Pharmacogenetics, Drug-Metabolizing Enzymes, and Clinical Practice

  title={Pharmacogenetics, Drug-Metabolizing Enzymes, and Clinical Practice},
  author={Sharon J. Gardiner and Evan James Begg},
  journal={Pharmacological Reviews},
  pages={521 - 590}
The application of pharmacogenetics holds great promise for individualized therapy. However, it has little clinical reality at present, despite many claims. The main problem is that the evidence base supporting genetic testing before therapy is weak. The pharmacology of the drugs subject to inherited variability in metabolism is often complex. Few have simple or single pathways of elimination. Some have active metabolites or enantiomers with different activities and pathways of elimination… 

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