Pharmacogenetics, Drug-Metabolizing Enzymes, and Clinical Practice
@article{Gardiner2006PharmacogeneticsDE, title={Pharmacogenetics, Drug-Metabolizing Enzymes, and Clinical Practice}, author={S. Gardiner and E. Begg}, journal={Pharmacological Reviews}, year={2006}, volume={58}, pages={521 - 590} }
The application of pharmacogenetics holds great promise for individualized therapy. However, it has little clinical reality at present, despite many claims. The main problem is that the evidence base supporting genetic testing before therapy is weak. The pharmacology of the drugs subject to inherited variability in metabolism is often complex. Few have simple or single pathways of elimination. Some have active metabolites or enantiomers with different activities and pathways of elimination… CONTINUE READING
Figures, Tables, and Topics from this paper
373 Citations
Genetic and Epigenetic Factors Affecting Cytochrome P450 Phenotype and Their Clinical Relevance
- Medicine
- 2012
- 4
- PDF
Review: Pharmacogenetic aspects of the effect of cytochrome P450 polymorphisms on serotonergic drug metabolism, response, interactions, and adverse effects
- Medicine
- Forensic science, medicine, and pathology
- 2011
- 56
- Highly Influenced
Genetic and Epigenetic Factors Affecting Cytochrome P 450 Phenotype and Their Clinical Relevance
- 2012
- PDF
Pharmacogenomics and adverse drug reactions in diagnostic and clinical practice
- Medicine
- Clinical chemistry and laboratory medicine
- 2007
- 26
Pharmacogenetics of drug-metabolizing enzymes: the prodrug hypothesis.
- Medicine
- Pharmacogenomics
- 2012
- 12
The role of pharmacogenetics in nonmalignant gastrointestinal diseases
- Medicine
- Nature Reviews Gastroenterology &Hepatology
- 2012
- 8
References
SHOWING 1-10 OF 1,094 REFERENCES
Pharmacogenetic testing for drug metabolizing enzymes: is it happening in practice?
- Medicine, Biology
- Pharmacogenetics and genomics
- 2005
- 81
The future prospects of pharmacogenetics in oral anticoagulation therapy.
- Medicine
- British journal of clinical pharmacology
- 2006
- 58
Pharmacogenetics of cytochrome P4502D6: genetic background and clinical implication
- Medicine
- European journal of clinical investigation
- 2003
- 196
Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response
- Medicine
- Molecular Psychiatry
- 2004
- 657
- PDF
Pharmacokinetics of Voriconazole and Cytochrome p450 2C19 Genetic Status
- Medicine
- Clinical pharmacology and therapeutics
- 2004
- 155
Metabolism and pharmacokinetics of phenelzine: lack of evidence for acetylation pathway in humans.
- Biology, Medicine
- Journal of clinical psychopharmacology
- 1985
- 33
Pharmacogenetics of Warfarin Elimination and its Clinical Implications
- Biology, Medicine
- Clinical pharmacokinetics
- 2001
- 311
Cancer pharmacogenomics: achievements in basic research
- Medicine
- International Journal of Clinical Oncology
- 2004
- 8
Clinical Consequences of Cytochrome P450 2C9 Polymorphisms
- Biology, Medicine
- Clinical pharmacology and therapeutics
- 2005
- 451