Pharmacogenetic variation and metformin response.

  title={Pharmacogenetic variation and metformin response.},
  author={Suning Chen and Kwok-Yung Yuen and Miaomiao Xi and Yanyan Jia and Yan Wong and Jinyi Zhao and Likun Ding and Jian Zhang and Aidong Wen},
  journal={Current drug metabolism},
  volume={14 10},
Diabetes is a major health problem worldwide, and metformin, a traditional oral anti-hyperglycemic drug, is now believed to be the most widely prescribed antidiabetic drug. Metformin acts primarily by inhibiting hepatic glucose production and improving insulin sensitivity. Metformin is absorbed predominately by the small intestine and excreted in an unaltered form in the urine. The pharmacokinetics of metformin is primarily determined by membrane transporters, including the plasma membrane… CONTINUE READING
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