Pharmacogenetic study of statin therapy and cholesterol reduction.

  title={Pharmacogenetic study of statin therapy and cholesterol reduction.},
  author={Daniel Chasman and David Posada and Lakshman Subrahmanyan and Nancy R. Cook and Vincent P. Stanton and Paul M. Ridker},
  volume={291 23},
CONTEXT Polymorphisms in genes involved in cholesterol synthesis, absorption, and transport may affect statin efficacy. OBJECTIVE To evaluate systematically whether genetic variation influences response to pravastatin therapy. DESIGN, SETTING, AND POPULATION The DNA of 1536 individuals treated with pravastatin, 40 mg/d, was analyzed for 148 single-nucleotide polymorphisms (SNPs) within 10 candidate genes related to lipid metabolism. Variation within these genes was then examined for… CONTINUE READING
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