Pharmacogenetic study of serotonin 6 receptor gene with antidepressant response in major depressive disorder in the Japanese population.

@article{Kishi2010PharmacogeneticSO,
  title={Pharmacogenetic study of serotonin 6 receptor gene with antidepressant response in major depressive disorder in the Japanese population.},
  author={Taro Kishi and Yasuhisa Fukuo and Reiji Yoshimura and Tomo Okochi and Tsuyoshi Kitajima and Hiroshi Naitoh and Wakako Umene-Nakano and Jun - Ichi Sagara Shugo Nakamura and Norio Ozaki and Nakao Iwata},
  journal={Human psychopharmacology},
  year={2010},
  volume={25 6},
  pages={481-6}
}
OBJECTIVE Several investigations have suggested that alterations in serotonin 6 (5-HT6) receptors might be associated with the pathophysiology of major depressive disorder (MDD), and that 5-HT6 receptors might be a therapeutic target for serotonin selective reuptake inhibitor (SSRI) in MDD. To evaluate the association between HTR6 and the efficacy of SSRI treatment in Japanese MDD patients, we conducted a case-control study in a Japanese population sample. METHODS We selected five tagging… CONTINUE READING

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