Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner

@inproceedings{Mitew2017PharmacogeneticSO,
  title={Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner},
  author={Stanislaw Mitew and Ilan Gobius and Laura R. Fenlon and Stuart J McDougall and David Hawkes and Yao Lulu Xing and Helena Bujalka and Andrew L Gundlach and Linda J. Richards and Trevor J. Kilpatrick and Tobias D Merson and Ben Emery},
  booktitle={Nature Communications},
  year={2017}
}
Mounting evidence suggests that neuronal activity influences myelination, potentially allowing for experience-driven modulation of neural circuitry. The degree to which neuronal activity is capable of regulating myelination at the individual axon level is unclear. Here we demonstrate that stimulation of somatosensory axons in the mouse brain increases proliferation and differentiation of oligodendrocyte progenitor cells (OPCs) within the underlying white matter. Stimulated axons display an… CONTINUE READING

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