Pharmacogenetic predictor of extrapyramidal symptoms induced by antipsychotics: multilocus interaction in the mTOR pathway.

@article{Mas2015PharmacogeneticPO,
  title={Pharmacogenetic predictor of extrapyramidal symptoms induced by antipsychotics: multilocus interaction in the mTOR pathway.},
  author={Sergi Mas and Patricia Gass{\'o} and Marie A Ritter and Carolina Malagelada and Miquel Bernardo and Amalia Lafuente},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  year={2015},
  volume={25 1},
  pages={51-9}
}
Antipsychotic (AP) treatment-emergent extrapyramidal symptoms (EPS) are acute adverse reactions of APs. The aim of the present study is to analyze gene-gene interactions in nine genes related to the mTOR pathway, in order to develop genetic predictors of the appearance of EPS. 243 subjects (78 presenting EPS: 165 not) from three cohorts participated in the present study: Cohort 1, patients treated with risperidone, (n=114); Cohort 2, patients treated with APs other than risperidone (n=102… CONTINUE READING
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