Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity.

  title={Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity.},
  author={Nielka P. van Erp and Karel Eechoute and Astrid A M van der Veldt and John B.A.G. Haanen and An K. L. Reyners and Ron H. J. Mathijssen and Epie Boven and Tahar van der Straaten and Ren{\'e}e F. Baak-Pablo and Judith A. M. Wessels and H. J. Guchelaar and Hans J Gelderblom},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={27 26},
  • N. V. van ErpK. Eechoute H. Gelderblom
  • Published 10 September 2009
  • Biology, Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
PURPOSE To identify genetic markers in the pharmacokinetic and pharmacodynamic pathways of sunitinib that predispose for development of toxicities: thrombocytopenia, leukopenia, mucosal inflammation, hand-foot syndrome, and any toxicity according to National Cancer Institute Common Toxicity Criteria higher than grade 2. PATIENTS AND METHODS A multicenter pharmacogenetic association study was performed in 219 patients treated with single-agent sunitinib. A total of 31 single nucleotide… 

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