Pharmacogenetic insights to monoaminergic dysfunction in alcohol dependence

@article{Heinz2004PharmacogeneticIT,
  title={Pharmacogenetic insights to monoaminergic dysfunction in alcohol dependence},
  author={Andreas Heinz and David Goldman and J{\"u}rgen Gallinat and Gunter Schumann and Imke Puls},
  journal={Psychopharmacology},
  year={2004},
  volume={174},
  pages={561-570}
}
Alcohol dependence is characterized by the development of tolerance, withdrawal symptoms, and craving for alcohol. Chronic alcohol consumption causes neuroadaptive changes in the central dopaminergic and serotonergic system, which are partially reversible after detoxification. The severity and time-course of recovery of these neuroadaptive changes may depend on the genetic constitution of monoamine transporters and receptors and contribute to the relapse risk of alcoholics. To assess the… CONTINUE READING
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1998a) In vivo observation of an association between serotonin transporters and sensitivity to alcohol intoxication

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Highly Influential
12 Excerpts

In vivo observation of an association between serotonin transporters and sensitivity to alcohol intoxication

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  • Am J Psychiatry
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Highly Influential
12 Excerpts

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