Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes.

@article{Hesse2004PharmacogeneticDO,
  title={Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes.},
  author={Leah M Hesse and Ping He and Soundararajan Krishnaswamy and Qin Hao and Kirk Hogan and Lisa L. von Moltke and David J Greenblatt and Michael H. Court},
  journal={Pharmacogenetics},
  year={2004},
  volume={14 4},
  pages={225-38}
}
Bupropion is primarily metabolized in human liver by cytochrome P450 (CYP) 2B6, an isoform that shows high interindividual variability in expression and catalysis. The aim of this study was to identify mechanisms underlying this variability through comprehensive phenotype-genotype analysis of a well-characterized human liver bank (n = 54). There was substantial variability in microsomal bupropion hydroxylation activities (over 45-fold) and CYP2B6 protein content (over 288-fold), with excellent… CONTINUE READING
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