Pharmacogenetic biomarkers: cytochrome P450 3A5.

  title={Pharmacogenetic biomarkers: cytochrome P450 3A5.},
  author={I Macphee},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  volume={413 17-18},
The immunosuppressive drugs used for solid organ transplantation all have a narrow therapeutic index with wide variation between individuals in the blood concentration achieved by a given dose. Therapeutic drug monitoring is employed routinely but may not allow optimisation of drug exposure during the critical period two to three days following transplantation. A key factor in the inter-individual variability for tacrolimus, and probably sirolimus, is whether an individual is genetically… CONTINUE READING


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