Pharmacogenetic analysis of sex differences in opioid antinociception in rats.

@article{Terner2003PharmacogeneticAO,
  title={Pharmacogenetic analysis of sex differences in opioid antinociception in rats.},
  author={Jolan M. Terner and Lisa Madonia Lomas and E Suzanne Smith and Andrew C. Barrett and Mitchell J. Picker},
  journal={Pain},
  year={2003},
  volume={106 3},
  pages={381-91}
}
Sex differences in opioid antinociception have been reported in rodents and monkeys, with opioids being more potent in males than females. In the present study, the influence of rat strain on sex differences in opioid antinociception was examined in a warm water tail-withdrawal procedure. Antinociceptive tests were conducted with the high-efficacy micro-opioid morphine, and the less efficacious opioids buprenorphine, butorphanol and nalbuphine. Baseline nociceptive latencies were consistently… CONTINUE READING

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