Pharmacogenetic Analysis of TNF, TNFRSF1A, and TNFRSF1B Gene Polymorphisms and Prediction of Response to Anti-TNF Therapy in Psoriasis Patients in the Greek Population

@article{Vasilopoulos2012PharmacogeneticAO,
  title={Pharmacogenetic Analysis of TNF, TNFRSF1A, and TNFRSF1B Gene Polymorphisms and Prediction of Response to Anti-TNF Therapy in Psoriasis Patients in the Greek Population},
  author={Dr Yiannis Vasilopoulos and Marilena Manolika and Efterpi Zafiriou and Theologia Sarafidou and Vasilis Bagiatis and Sabine Kr{\"u}ger-Krasagaki and Androniki D. Tosca and A Patsatsi and Dimitris Sotiriadis and Zissis Mamuris and Angeliki Roussaki-Schulze},
  journal={Molecular Diagnosis & Therapy},
  year={2012},
  volume={16},
  pages={29-34}
}
Background: Although biologic therapies have revolutionized the treatment of psoriasis, patients exhibit a substantial heterogeneous response that could be due to complex genetic heterogeneity. Objective: The aim of this study was to investigate the possible influence of tumor necrosis factor-α (TNF), TNF receptor I (TNFRSF1A), and TNF receptor II (TNFRSF1B) gene polymorphisms on anti-TNF treatment responsiveness in psoriasis patients. Methods: A Greek multicenter collaboration was established… CONTINUE READING
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